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Cagrilintide
🍽️
Cagrilintide
Fat loss
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Long-acting amylin analog studied for satiety and weight loss.
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Class
Amylin, fat loss
Forms
Injectable
Typical dose
0.3 to 2.4 mg/week
Cycle
Ongoing, titrated
Onset
Fullness in 1 to 2 weeks
Tolerance
Nausea early, then eases
Educational summary. See Sources & research below for the underlying studies.
What it is
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Cagrilintide is a long-acting amylin analog that makes you feel full, often paired with semaglutide.
• Best for: appetite control, especially stacked with a GLP-1
• Pairing: the CagriSema combo with semaglutide
• Status: investigational, sold for research
How it works
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It mimics amylin, a hormone that signals fullness.
• Tells the brain you are satisfied sooner
• Slows stomach emptying so meals last longer
• Complements GLP-1s rather than copying them
Dosing and mixing
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Reference tiers only. Track the dose you are already taking.
Low
0.3 mg, once weekly
FOR Easing in, the first few weeks
BENEFIT Often picked as a lower-exposure tier to assess fullness and nausea
Standard
1 to 1.7 mg, once weekly
FOR Steady appetite control for most
BENEFIT Commonly picked by people interested in reported satiety alongside a GLP-1
High
2.4 mg, once weekly
FOR Max range after titration
BENEFIT People report the strongest appetite effect here, with more nausea
Schedule: One injection per week, same day. Rotate sites.
Beginner ramp: Step up every 4 weeks as tolerated.
Mixing (reconstitution)
BAC water is bacteriostatic water, the sterile water you mix in.
A 5 mg vial with 2 mL BAC water is a common starting point.
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Ranges are reference only, not a recommendation. See Sources & research below.
How to take it
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Inject under the skin once a week.
• Same day each week, rotate the spot
• Refrigerate the mixed vial between doses
What to expect
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Weeks 1 to 2
Meals feel more filling. Mild nausea as you adjust.
Weeks 3 to 6
Smaller portions feel natural and appetite is quieter.
Months 2 to 4
Steady support, strongest when stacked with a GLP-1.
Plateaus
Normal, a careful dose increase can help.
Keep in mind
Most data is from the CagriSema pairing, not solo use.
Side effects
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Commonly reported
• Nausea, especially early
• Reduced appetite
• Constipation
See a clinician if
• Severe or non-stop vomiting
• Severe abdominal pain
Storage
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Keep it cold, before and after mixing.
• Powder: refrigerate
• After mixing: fridge, use within about 4 weeks
• Do not freeze, keep out of light
Common stacks
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• Cagrilintide + Semaglutide: a common pairing for people interested in CagriSema research
• Cagrilintide + BPC-157: people pair these when GI comfort is a concern during a dose ramp
Sources & research
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Cagrilintide plus semaglutide showed strong weight loss in studies.
CagriSema trials · Enebo et al., Lancet 2021 ↗
Status
Still investigational, long-term data is limited.
Sources are provided for education and are not exhaustive. Where a source names a specific trial or journal it is shown above; always confirm with a licensed clinician.
Educational and research information only. Not medical advice. Always confirm dosing and safety with a licensed clinician.
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