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Liraglutide
📆
Liraglutide
Fat loss
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GLP-1 agonist (it acts like the gut hormone that curbs hunger), an earlier generation of the class.
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Class
GLP-1, fat loss
Forms
Injectable
Typical dose
0.6 to 3 mg/day
Cycle
Ongoing, daily
Onset
Appetite drop in 1 to 2 weeks
Tolerance
Nausea early, then eases
Educational summary. See Sources & research below for the underlying studies.
What it is
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Liraglutide is a daily GLP-1, an earlier generation of the weight-loss peptides.
• Best for: those who prefer or tolerate daily dosing
• Note: weekly options like semaglutide are now more common
• Track record: long and well studied
How it works
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It mimics GLP-1 to curb appetite, but is shorter-acting.
• Curbs appetite and slows stomach emptying
• Shorter duration, so it is dosed daily
• Also improves blood sugar
Dosing and mixing
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Reference tiers only. Track the dose you are already taking.
Low
0.6 mg, once daily
FOR The starting dose, the first week
BENEFIT Often picked as a lower-exposure starting tier to assess nausea
Standard
1.2 to 1.8 mg, once daily
FOR Blood sugar and modest weight goals
BENEFIT Commonly picked as the middle range in liraglutide discussions
High
3 mg, once daily
FOR Dedicated weight loss, after titration
BENEFIT People report the strongest appetite effect at this tier
Schedule: One injection per day, ideally same time. Rotate sites.
Beginner ramp: Increase about weekly as tolerated.
Ranges are reference only, not a recommendation. See Sources & research below.
How to take it
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Inject under the skin once a day.
• Pick a consistent time daily
• Rotate the spot to avoid irritation
• Refrigerate the mixed vial between doses
What to expect
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Weeks 1 to 2
Appetite starts to quiet. Mild nausea as you adjust.
Weeks 3 to 8
Steady, modest loss as you titrate the daily dose.
Months 2 to 6
Main loss window with consistent daily dosing.
Plateaus
Normal, a careful increase can help.
Keep in mind
Daily dosing means consistency matters more here.
Side effects
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Commonly reported
• Nausea, especially early
• Reduced appetite
• Constipation
See a clinician if
• Severe or non-stop vomiting
• Severe abdominal pain
Storage
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Keep it cold, before and after mixing.
• Powder: refrigerate
• After mixing: fridge, use within about 4 weeks
• Do not freeze, keep out of light
Common stacks
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• Liraglutide + BPC-157: people pair these when GI comfort is a concern during a dose ramp
Sources & research
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Showed weight loss versus placebo in the trial.
SCALE trials · Pi-Sunyer et al. (SCALE), NEJM 2015 ↗
Cardiovascular and blood-sugar benefits in diabetes.
LEADER trial · Marso et al. (LEADER), NEJM 2016 ↗
Sources are provided for education and are not exhaustive. Where a source names a specific trial or journal it is shown above; always confirm with a licensed clinician.
Educational and research information only. Not medical advice. Always confirm dosing and safety with a licensed clinician.
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