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LL-37
🦠
LL-37
Immune
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Antimicrobial peptide studied for innate immunity.
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Class
Immune, antimicrobial
Forms
Injectable
Typical dose
Short cycles (varies)
Cycle
Short cycles
Onset
Over weeks
Tolerance
Injection-site reactions
Educational summary. See Sources & research below for the underlying studies.
What it is
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LL-37 is a natural antimicrobial peptide studied for innate immune defense and microbial balance.
• Best for: microbial balance and immune defense
• Also studied for: gut and tissue repair
• Evidence: mostly preclinical so far
How it works
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It attacks microbes and rallies the immune system.
• Directly disrupts bacteria and biofilms
• Coordinates the innate immune response
• Supports tissue repair too
Dosing and mixing
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Reference tiers only. Track the dose you are already taking.
Low
Low dose, every other day
FOR Gentle start, sensitive users
BENEFIT Often picked as the lower-frequency tier while users assess site reactions
Standard
Daily, short cycle
FOR Microbial balance and defense
BENEFIT The short-course cadence most often cited in LL-37 discussions
High
Higher daily, short term
FOR Stubborn issues, advanced
BENEFIT A higher-exposure tier, with more site reactions reported
Schedule: Subcutaneous in short cycles, not continuously.
Beginner ramp: Dosing is not well standardized, so start low.
Mixing (reconstitution)
BAC water is bacteriostatic water, the sterile water you mix in.
A 5 mg vial with 2 mL BAC water is a common starting point.
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Ranges are reference only, not a recommendation. See Sources & research below.
How to take it
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Inject under the skin in a short cycle.
• Injection-site reactions are common
• Rotate the spot to avoid irritation
• Refrigerate the mixed vial between doses
What to expect
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Week 1
Possible injection-site redness as you start.
Weeks 2 to 4
Microbial and immune support builds.
Keep in mind
Human data is limited, keep cycles short.
Side effects
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Commonly reported
• Injection-site reaction, sometimes notable
See a clinician if
• Signs of an allergic reaction
Storage
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Keep it cold, before and after mixing.
• Powder: refrigerate
• After mixing: fridge, use within about 4 weeks
• Do not freeze, keep out of light
Common stacks
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• LL-37 + BPC-157: people pair these when both antimicrobial and gut research are relevant
Sources & research
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Antimicrobial studies
A natural cathelicidin that disrupts microbes and biofilms.
Human data
Mostly preclinical, so keep use cautious and short.
Sources are provided for education and are not exhaustive. Where a source names a specific trial or journal it is shown above; always confirm with a licensed clinician.
Educational and research information only. Not medical advice. Always confirm dosing and safety with a licensed clinician.
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