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Melanotan I
☀️
Melanotan I
Skin & hair
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Tanning peptide studied for pigment and photoprotection.
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Class
Tanning, skin
Forms
Injectable
Typical dose
0.25 to 1 mg/day (load)
Cycle
Load then maintain
Onset
Tan over 1 to 2 weeks
Tolerance
Milder than MT-II
Educational summary. See Sources & research below for the underlying studies.
What it is
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Melanotan I is a tanning peptide that darkens skin with fewer side effects than Melanotan II.
• Best for: a tan and some sun protection
• Edge: gentler than Melanotan II, less libido effect
• Still requires some UV to tan
How it works
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It tells your skin to make more pigment.
• Activates melanocortin receptors
• Increases melanin (skin pigment)
• More targeted to skin than MT-II
Dosing and mixing
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Reference tiers only. Track the dose you are already taking.
Low
0.25 mg/day, loading
FOR Fair skin or easing in
BENEFIT Often picked as the lower-exposure loading tier while users assess nausea
Standard
0.5 to 1 mg/day, loading
FOR Building a base tan
BENEFIT The loading range most often cited in Melanotan I discussions
High
1 mg/day, then maintenance
FOR Faster tanning, then upkeep
BENEFIT A higher loading tier, with a maintenance transition commonly discussed
Schedule: Daily during loading, then 2 to 3 times weekly to maintain.
Beginner ramp: Start low to gauge nausea, then build the loading dose.
Mixing (reconstitution)
BAC water is bacteriostatic water, the sterile water you mix in.
A 10 mg vial with 2 mL BAC water is a common starting point.
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Ranges are reference only, not a recommendation. See Sources & research below.
How to take it
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Inject under the skin once a day during loading.
• Some UV exposure is still needed to tan
• Rotate the spot to avoid irritation
• Refrigerate the mixed vial between doses
What to expect
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Week 1
Mild nausea or flushing as you start.
Weeks 1 to 2
Skin begins to tan with some sun.
Weeks 3 to 4
Tan deepens, then drop to maintenance.
Keep in mind
Watch moles and freckles, they can darken.
Side effects
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Commonly reported
• Nausea early on
• Darkening of moles and freckles
See a clinician if
• Any new or changing mole
Storage
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Keep it cold, before and after mixing.
• Powder: refrigerate
• After mixing: fridge, use within about 4 weeks
• Do not freeze, keep out of light
Common stacks
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• Melanotan I: people usually discuss it as a standalone compound
Sources & research
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The medical version (afamelanotide) is used for light-sensitivity conditions.
Photoprotection use · Langendonk & Balwani et al., NEJM 2015 ↗
Practical note
Gentler than Melanotan II, but still darkens moles.
Sources are provided for education and are not exhaustive. Where a source names a specific trial or journal it is shown above; always confirm with a licensed clinician.
Educational and research information only. Not medical advice. Always confirm dosing and safety with a licensed clinician.
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