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MK-677 (Ibutamoren)
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MK-677 (Ibutamoren)
Muscle / GH
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Oral growth-hormone secretagogue (it nudges your body to release its own growth hormone).
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Class
Oral GH secretagogue
Forms
Oral
Typical dose
10 to 25 mg/day
Cycle
Ongoing or in blocks
Onset
Hunger and sleep in days
Tolerance
Hunger, water retention
Educational summary. See Sources & research below for the underlying studies.
What it is
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MK-677 is an oral growth-hormone secretagogue (it nudges your body to release its own growth hormone), taken as a pill not an injection, that raises GH and IGF-1 around the clock.
• Best for: a needle-free GH boost
• Edge: a convenient daily pill
• Note: increases appetite and water retention
How it works
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It mimics ghrelin to keep GH and IGF-1 elevated all day.
• Sustains higher GH and IGF-1, not just pulses
• Taken orally, so no injecting
• Drives hunger and some water retention
Dosing and mixing
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Reference tiers only. Track the dose you are already taking.
Low
10 mg/day
FOR Sleep and gentle support
BENEFIT Often picked as the lower-exposure tier in sleep and hunger discussions
Standard
15 to 25 mg/day
FOR Recovery, appetite, body comp
BENEFIT The range most often cited in MK-677 discussions
High
25 mg/day, longer run
FOR Aggressive bulking goals
BENEFIT A higher-exposure tier, with water retention and hunger more often reported
Schedule: Once daily, often at night. Some cycle it in blocks.
Beginner ramp: Start at 10 mg to gauge water retention and hunger.
Ranges are reference only, not a recommendation. See Sources & research below.
How to take it
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Taken by mouth once a day, no injecting needed.
• Night dosing helps some with sleep
• Expect more appetite and some water weight
What to expect
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Days 1 to 3
Noticeably more appetite, often deeper sleep.
Weeks 1 to 2
Some water retention and fuller muscles.
Weeks 4 to 12
Recovery and size build with the extra food.
Keep in mind
Water weight and hunger are normal, not fat gain by itself.
Side effects
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Commonly reported
• Increased hunger
• Water retention
• Lethargy in some
See a clinician if
• Numbness or tingling, or blood-sugar changes
Storage
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Store dry and cool.
• Keep in a cool, dry place away from light
• No refrigeration needed
Common stacks
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• MK-677 + a GLP-1: people pair these when MK-related hunger is a concern
Sources & research
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Raises GH and IGF-1 and can support lean mass.
Clinical studies · Nass et al., Ann Intern Med 2008 ↗
Practical note
Water retention and hunger are the usual trade-offs.
Sources are provided for education and are not exhaustive. Where a source names a specific trial or journal it is shown above; always confirm with a licensed clinician.
Educational and research information only. Not medical advice. Always confirm dosing and safety with a licensed clinician.
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