✕
MOTS-c
🔋
MOTS-c
Longevity
About
History
Charts
Records
Mitochondrial peptide studied for metabolism and endurance.
Track MOTS-c free
Calculate your exact dose, log every injection, and never miss one. No account needed.
→
Class
Longevity, metabolic
Forms
Injectable
Typical dose
10 mg, 2 to 3x/week
Cycle
4 to 8 weeks
Onset
Endurance over weeks
Tolerance
Generally well tolerated
Educational summary. See Sources & research below for the underlying studies.
What it is
›
MOTS-c is a mitochondrial peptide studied for metabolism, insulin sensitivity, and endurance.
• Best for: metabolic health and exercise capacity
• Edge: acts like an exercise-mimicking signal
• Popular with athletes and biohackers
How it works
›
It flips on the cell energy switch tied to exercise.
• Acts on AMPK, a key metabolic pathway
• Improves how cells use energy
• Supports insulin sensitivity
Dosing and mixing
›
Reference tiers only. Track the dose you are already taking.
Low
5 mg, twice weekly
FOR Gentle metabolic support
BENEFIT Often picked as the lower-frequency tier in metabolic research discussions
Standard
10 mg, 2 to 3x weekly
FOR Metabolism and endurance for most
BENEFIT The cadence most often cited in MOTS-c discussions
High
10 mg, every other day
FOR Athletes pushing endurance
BENEFIT A higher-frequency tier discussed in athlete-focused research
Schedule: Subcutaneous 2 to 3 times per week, 4 to 8 week blocks.
Beginner ramp: Start at the standard cadence, pair with training.
Mixing (reconstitution)
BAC water is bacteriostatic water, the sterile water you mix in.
A 10 mg vial with 2 mL BAC water is a common starting point.
Calculate my dose →
Ranges are reference only, not a recommendation. See Sources & research below.
How to take it
›
Inject under the skin a few times per week.
• Often timed around training days
• Rotate the spot to avoid irritation
• Refrigerate the mixed vial between doses
What to expect
›
Weeks 1 to 2
Subtle, best felt alongside training.
Weeks 3 to 6
Better endurance and metabolic feel for some.
Weeks 6 to 8
Main window, then a break.
Keep in mind
It works with exercise, not as a replacement for it.
Side effects
›
Commonly reported
• Generally well tolerated
• Occasional injection-site irritation
See a clinician if
• Signs of an allergic reaction
Storage
›
Keep it cold, before and after mixing.
• Powder: refrigerate
• After mixing: fridge, use within about 4 weeks
• Do not freeze, keep out of light
Common stacks
›
• MOTS-c + NAD+: people pair these when both metabolic and NAD research are relevant
Sources & research
›
Metabolic studies
Improved metabolism and exercise capacity in animal models.
Mechanism
Acts like an exercise signal through the AMPK pathway.
Sources are provided for education and are not exhaustive. Where a source names a specific trial or journal it is shown above; always confirm with a licensed clinician.
Educational and research information only. Not medical advice. Always confirm dosing and safety with a licensed clinician.
+ Track this
Track
Peptides
Calc
Progress