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Semaglutide
📉
Semaglutide
Fat loss
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GLP-1 agonist (it acts like the gut hormone that curbs hunger), the original mainstream weight-loss peptide.
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Class
GLP-1, fat loss
Forms
Injectable, also oral
Typical dose
0.25 to 2.4 mg/week
Cycle
Ongoing, titrated
Onset
Appetite drop in 1 to 2 weeks
Tolerance
Nausea early, then eases
Educational summary. See Sources & research below for the underlying studies.
What it is
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Semaglutide is the GLP-1 that made peptide weight loss mainstream.
• Best for: a proven, familiar first GLP-1
• Track record: the most widely used and studied in its class
• Note: gentler and slower than Tirzepatide or Retatrutide for many
How it works
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It mimics the gut hormone GLP-1 to reduce hunger.
• Curbs appetite and quiets food cravings
• Slows stomach emptying so you feel full longer
• Also improves insulin and blood sugar
Dosing and mixing
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Reference tiers only. Track the dose you are already taking.
Low
0.25 mg, once weekly
FOR The starting dose, the first 4 weeks
BENEFIT Often picked as a lower-exposure starting tier to assess nausea
Standard
0.5 to 1 mg, once weekly
FOR Steady weight loss for most people
BENEFIT Commonly picked as the middle range in semaglutide discussions
High
1.7 to 2.4 mg, once weekly
FOR Max range after full titration
BENEFIT People report stronger appetite effects here, with more GI effects
Schedule: One injection per week, same day. Rotate sites.
Beginner ramp: Increase about every 4 weeks, rushing it causes most nausea.
Mixing (reconstitution)
BAC water is bacteriostatic water, the sterile water you mix in.
A 5 mg vial with 2 mL BAC water is a common, easy-to-draw mix.
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Ranges are reference only, not a recommendation. See Sources & research below.
How to take it
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Inject under the skin once a week (abdomen, thigh, or upper arm).
• Same day each week, rotate the spot
• Refrigerate the mixed vial between doses
What to expect
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Weeks 1 to 2
Appetite starts to quiet. Mild nausea as you adjust.
Weeks 3 to 8
Portions shrink and steady loss begins as you titrate.
Months 2 to 6
The main loss window with consistent dosing.
Months 6 and on
Loss levels off near your dose, maintenance begins.
Plateaus
Normal, a careful dose increase usually helps.
Keep in mind
Protein and training protect muscle during loss.
Side effects
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Commonly reported
• Nausea, especially early
• Constipation
• Reduced appetite
• Fatigue early on
See a clinician if
• Severe or non-stop vomiting
• Severe abdominal pain
• Right-side pain (possible gallbladder)
Storage
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Keep it cold, before and after mixing.
• Powder: refrigerate, it handles short room-temp and shipping
• After mixing: fridge, use within about 4 weeks
• Do not freeze, keep out of light, swirl gently
Common stacks
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• Semaglutide + BPC-157: people pair these when GI comfort is a concern during a dose ramp
• Semaglutide + Cagrilintide: a common pairing for people interested in CagriSema research
Sources & research
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Demonstrated significant weight loss versus placebo.
STEP trials · Wilding et al. (STEP 1), NEJM 2021 ↗
Strong blood-sugar control in diabetes studies.
SUSTAIN trials · Marso et al. (SUSTAIN-6), NEJM 2016 ↗
Sources are provided for education and are not exhaustive. Where a source names a specific trial or journal it is shown above; always confirm with a licensed clinician.
Educational and research information only. Not medical advice. Always confirm dosing and safety with a licensed clinician.
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