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SS-31 (Elamipretide)
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SS-31 (Elamipretide)
Longevity
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Mitochondria-targeted peptide studied for cellular energy.
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Class
Longevity, mito
Forms
Injectable
Typical dose
5 to 10 mg/day
Cycle
Cycled
Onset
Energy over weeks
Tolerance
Generally well tolerated
Educational summary. See Sources & research below for the underlying studies.
What it is
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SS-31 concentrates in mitochondria to support cellular energy, studied for heart, muscle, and eyes.
• Best for: energy, mitochondrial and heart-muscle health
• Edge: targets the cell power plant directly
• Evidence: active clinical research
How it works
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It stabilizes the membranes where cells make energy.
• Binds cardiolipin in the mitochondrial membrane
• Steadies energy production
• Lowers oxidative stress
Dosing and mixing
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Reference tiers only. Track the dose you are already taking.
Low
5 mg/day
FOR Easing in or gentle support
BENEFIT Often picked as the lower-exposure tier in mitochondrial research discussions
Standard
10 mg/day, in cycles
FOR Energy and recovery for most
BENEFIT The range most often cited in SS-31 research
High
10 mg or more/day, longer cycle
FOR Dedicated mitochondrial protocols
BENEFIT A higher-exposure, longer-cycle tier discussed in dedicated protocols
Schedule: Daily subcutaneous in cycles of several weeks.
Beginner ramp: Start at the standard dose, adjust by response.
Mixing (reconstitution)
BAC water is bacteriostatic water, the sterile water you mix in.
A 50 mg vial with 2 mL BAC water is a common starting point.
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Ranges are reference only, not a recommendation. See Sources & research below.
How to take it
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Inject under the skin once a day.
• Same time daily is easiest
• Rotate the spot to avoid irritation
• Refrigerate the mixed vial between doses
What to expect
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Weeks 1 to 2
Subtle, mitochondria respond slowly.
Weeks 3 to 6
Some notice steadier energy and endurance.
Weeks 6 to 12
Main window for mitochondrial support.
Keep in mind
Effects are gradual, not stimulant-like.
Side effects
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Commonly reported
• Injection-site reaction
See a clinician if
• Signs of an allergic reaction
Storage
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Keep it cold, before and after mixing.
• Powder: refrigerate
• After mixing: fridge, use within about 4 weeks
• Do not freeze, keep out of light
Common stacks
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• SS-31 + NAD+: people pair these when both mitochondrial and NAD research are relevant
Sources & research
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Studied in primary mitochondrial myopathy (muscle).
Mitochondrial myopathy trial · Karaa et al. (MMPOWER), Neurology 2018 ↗
Mechanism
Protects cardiolipin, key to stable energy production.
Sources are provided for education and are not exhaustive. Where a source names a specific trial or journal it is shown above; always confirm with a licensed clinician.
Educational and research information only. Not medical advice. Always confirm dosing and safety with a licensed clinician.
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