✕
Tirzepatide
⚖️
Tirzepatide
Fat loss
About
History
Charts
Records
Dual GIP/GLP-1 agonist (it switches on two appetite receptors) for appetite control and fat loss.
Track Tirzepatide free
Calculate your exact dose, log every injection, and never miss one. No account needed.
→
Class
GLP-1, fat loss
Forms
Injectable
Typical dose
5 to 15 mg/week
Cycle
Ongoing, titrated
Onset
Appetite drop in week 1
Tolerance
Nausea early, then eases
Educational summary. See Sources & research below for the underlying studies.
What it is
›
Tirzepatide is a dual GIP/GLP-1 agonist, one of the most effective and popular fat-loss peptides.
• Best for: a strong, well-studied first GLP-1 for weight loss
• Also studied for: blood-sugar control
• Reputation: big results with a long real-world track record
How it works
›
It combines two gut hormones that work together on appetite.
• GLP-1: curbs appetite and slows stomach emptying
• GIP: adds appetite control and improves insulin response
• Together they quiet hunger more than GLP-1 alone
Dosing and mixing
›
Reference tiers only. Track the dose you are already taking.
Low
2.5 mg, once weekly
FOR The starting dose, the first 4 weeks
BENEFIT Often picked as a lower-exposure starting tier to assess nausea
Standard
5 to 10 mg, once weekly
FOR Steady fat loss for most people
BENEFIT Commonly picked as the middle range in appetite and weight discussions
High
12.5 to 15 mg, once weekly
FOR Max range after full titration, if tolerated
BENEFIT People report stronger appetite effects here, with more GI side effects
Schedule: One injection per week, same day. Rotate sites.
Beginner ramp: Step up by 2.5 mg every 4 weeks as tolerated.
Mixing (reconstitution)
BAC water is bacteriostatic water, the sterile water you mix in.
A 10 mg vial with 2 mL BAC water is a common, easy-to-draw mix.
Calculate my dose →
Ranges are reference only, not a recommendation. See Sources & research below.
How to take it
›
Inject under the skin once a week (abdomen, thigh, or upper arm).
• Keep the same day each week
• Rotate the spot to avoid irritation
• Refrigerate the mixed vial between doses
What to expect
›
Week 1
Appetite drops and food noise fades. Mild nausea as you adjust.
Weeks 2 to 4
Smaller portions feel normal. Some early water-weight drop.
Weeks 4 to 12
Steady fat loss as you titrate up. The main progress phase.
Months 3 to 12
Loss continues, then levels off near your dose ceiling.
Plateaus
Normal. A careful dose increase usually restarts progress.
Keep in mind
Prioritize protein and lifting to keep muscle while losing fat.
Side effects
›
Commonly reported
• Nausea, especially early or after increases
• Constipation or diarrhea
• Reduced appetite
• Burping or reflux
See a clinician if
• Severe or non-stop vomiting
• Severe abdominal pain (possible pancreatitis)
• Right-side pain (possible gallbladder)
Storage
›
Keep it cold, before and after mixing.
• Powder: refrigerate, it handles short room-temp and shipping
• After mixing: fridge, use within about 4 weeks
• Do not freeze, keep out of light, swirl gently
Common stacks
›
• Tirzepatide + BPC-157: people pair these when GI comfort is a concern during GLP-1 use
• Tirzepatide + Glutathione: people pair these when antioxidant use is part of their routine
• Tirzepatide + CJC-1295/Ipamorelin: an advanced pairing people choose when muscle retention is a concern
Sources & research
›
Showed large, sustained weight loss versus placebo.
SURMOUNT trials · Jastreboff et al. (SURMOUNT-1), NEJM 2022 ↗
Strong blood-sugar control in type 2 diabetes studies.
SURPASS trials · Frias et al. (SURPASS-2), NEJM 2021 ↗
Sources are provided for education and are not exhaustive. Where a source names a specific trial or journal it is shown above; always confirm with a licensed clinician.
Educational and research information only. Not medical advice. Always confirm dosing and safety with a licensed clinician.
+ Track this
Track
Peptides
Calc
Progress